WASHINGTON:
Are you looking for permanent freedom from smoking? Try these new potential drugs to quit smoking.
Researchers at Washington State University created more than a dozen candidate drugs with the potential to curb smokers’ desire for nicotine by slowing how it is broken down in the body. They hoped that the substances could help people reduce their consumption of tobacco, if not quit altogether.
The discovery targets a liver enzyme, called CYP2A6, which metabolizes nicotine. Researchers found that people who have fewer copies of a gene for the enzyme tend to smoke less and are less likely to be addicted to smoking.
Nicotine triggers the release of dopamine and serotonin, two pleasure-causing chemicals produced by the body. But as it gets metabolized, users can experience withdrawal symptoms like tingling in the hands and feet, sweating, anxiety, and irritability.
They also designed dozens of molecules that bind to CYP2A6 and inhibit its ability to metabolize nicotine.
“If you inhibit CYP2A6, it shouldn’t bother your overall health. If we could specifically target this enzyme, people should be fine, and it will possibly help them stop smoking or at least decrease their amount of smoking,” said Philip Lazarus, co-author of the study.
So far, the researchers have tested their candidate drugs to make sure they don’t disrupt other major enzymes that help the body metabolize other substances. This helped narrow the number of potential drugs down to 18.
The findings appeared in the Journal of Medicinal Chemistry. (ANI)
more recommended stories
Indulge in Festive Treats Without GuiltWith the festive season fast approaching,.
Stroke Day Observed at Amrita HospitalKOCHI:In observance of World Stroke Day,.
Recognizing the Signs of Stroke: A LifesaverBy Dr. Kumar MuthukumarApollo Adlux Hospital,Angamaly,.
World Occupational Therapy Day Celebrated by AIOTA in MumbaiMUMBAI:The All India Occupational Therapists’ Association.
Aster India Reports Strong Revenue and EBITDA PerformanceKOCHI:Aster DM Healthcare, one of the.
Prayatna Conducts Early Identification Training for Anganwadi TeachersKOCHI:As part of Occupational Therapy Month,.
CSIR-NIIST to Have Centres of Excellence in Ayurveda, Performance ChemicalsTHIRUVANANTHAPURAM:In a major step towards the.
Dozee Shravan – AI-Powered Remote Parent Health Monitoring Service Launched For NRIsKOCHI:Dozee, India’s Health AI leader, has.
Aster Guardians Global Nursing Award Announces Top 10 finalists for 2024BENGALURU/DUBAI:Aster DM Healthcare has today unveiled.
Aster Volunteers Launch New Mobile Medical Service in Katihar, BiharKOCHI:Aster Volunteers, the global CSR arm.