A researcher from Andhra University in Andhra Pradesh has come out with an innovative and novel solution for curing patients suffering with cancer disease relating to large intestine and uterus.
Dr Pullapukuri Kalyani, young Microbiology scientist from the department of Microbiology of Andhra University, had during her four year PhD research programme found a novel bio-active compound from the clay in Bay of Bengal for prevention and cure for patients suffering from large intestine and uterus cancer disease.
Dr Kalyani who is a native of Kakinada of East Godavari district had earlier got admitted into PhD programme in the department of Microbiology under the guidance of Professor K P J Hemalatha, research director from Andhra University and had selected the most complicated and critical subject of unearthing new antibacterial energy by dividing the fungi from the clay.
After continuous four years of rigorous research study, the young researcher could finally emerge with a new finding that paves way for curing dreaded disease like colon cancer. Kalyani could find the bio-active compound—2, 5 dioxocyclopentylamino-7-oxo-hepta-1, 3, 5-trienyl-2, 5 dihydroxy3-chlorophenyl-2, 4, 6trimethyldeca-2, 6-dienamide.
The university authorities after careful screening of the research paper submitted by Dr Kalyani accorded a PhD degree for her innovative research which is very much helpful in developing a novel solution for curing the large intestine and uterus cancer disease in patients.
“The main objective and aim of my study is to isolate the secondary metabolite producing fungi with various environmental applications from marine environment as it represents an unexplored source for isolation of new microbes (bacteria, fungi, actinomycetes, cyanobacteria and diatoms) that are potent producers of bio-active secondary metabolites. Among marine micro-organisms, particularly fungi have gained an important role as a source of biologically active secondary metabolites, by studying the colony characteristics, 20 isolates were screened from marine soil sample,” informed Kalyanai.
The researcher followed the disc diffusion method to screen the human pathogens and found that only twenty isolated fungal strains exhibited antibacterial activity against human pathogens. The compound was active against the cell lines. The compound effectively killed 50 per cent of the cancer cell lines. The Aspergiullus fumigates strain MF1 showed the efficiency to synthesise the silver nano particles. Maximum absorption was observed at 420nm after 72 hours of incubation, explained Dr Kalyani.
The fungus which is divided from the clay of the blue waters can also used to prevent the pollution from the textile dyeing. After her successful laboratory research activity, Dr Kalyani is now gearing up to kick-start in vivo anti cancer activity on rats.
