In a study, published in the International Journal of Environmental Research and Public Health, leading doctors in two reputed hospitals in Delhi have reported that over 4.9 lakh persons in India developed paralysis between 2000 to 2017 because of oral polio vaccine (OPV). The study calls for judicious use of OPV schedule to prevent vaccine induced paralysis.
Jacob Puliyel, a pediatrician at St Stephens Hospital in Delhi and co-workers say their study has shown that the frequency of pulse polio administration is directly or indirectly related to the incidence of non-polio acute flaccid paralysis (NPAFP). Puliyel’s team included Dr Rachana Dhiman and Dr Sandeep Prakash at St. Stephens Hospital and Dr V. Sreenivas of the All India Institute of Medical Sciences’ (AIIMS), Delhi.
To monitor progress in polio eradication, the WHO recommends that countries conduct surveillance for cases o acute flaccid paralysis (AFP) which is defined as a sudden onset of paralysis or weakness in any part of the body of a child less than15 years of age.
The surveillance allows nations to detect paralytic poliomyelitis due to wild poliovirus transmission in the population. There are many causes of AFP, so each case needs to be evaluated to find out if the paralysis is due to polio or not. This investigation includes testing stool specimens of all AFP cases for polio virus detection.
More than 50,000 AFP cases are investigated in India every year as part of this surveillance system that has been in place since 1997.
In 2009, 741 of these AFP cases in India tested positive for polio. In 2010 only 42 cases tested positive while in 2011 only a single AFP case tested positive for polio. Not a single AFP case tested positive for polio in 2012, 2013 and 2014. All AFP cases during the last three years have been due to non-polio causes.
The last case of polio from India was reported in 2011 but India even after it was certified polio-free maintains its surveillance system in order to pick up any imported cases of polio.
In the absence of wild polio transmission, it was expected that the AFP cases in India would reduce to acceptable rate of around 2 per 100,000. “Although surveillance in India has been exemplary, this has not yet materialized,” the report says. The AFP rate in some states is as high as 30 per 100,000.
The present study – using surveillance data obtained from all 36 states and Union Territories– was done to see if the incidence of NPAFP declined with reduction in pulse polio immunization rounds.
The results however showed that the number of pulse polio rounds conducted in a state had a “high correlation” with the NPAFP rate in the state.
The NPAFP rates in the states of Uttar Pradesh and Bihar were the highest in the country. “Our study found that NPAFP rate in these states was high in those years when the number of pulse polio rounds conducted was high,” the authors say.
For instance, in 2011, there were an additional 47,500 children with paralysis which was over and above the assumed NPAFP rate of 2 per 100,000 and the NPAFP rate started to decrease from 2012 when the number of pulse polio rounds had decreased.
“From the results, the NPAFP rate has been shown to decline with a reduction in the pulse polio doses suggesting that OPV vaccinations are responsible for the paralysis,” the authors say.
“A total of 640,000 children developed NPAFP in the years 2000–2017, suggesting that there were an additional 491,000 paralyzed children above the numbers expected to develop NPAFP,” the authors say.
According to their report “repeated doses of the live vaccine virus delivered to the intestine may colonize the gut and alter the viral microbiome of the intestine.”
Also studies from Finland and Turkey suggest that Guillain Barre Syndrome (GBS) is causatively associated with OPV vaccination campaigns.
“While the mechanism involved is speculative, our findings supports the hypothesis that the frequency of pulse polio administration is directly or indirectly related to the incidence of NPAFP,” the report says. “Now that India has been polio-free for over six years, we may be able to reduce NPAFP by further reducing pulse polio rounds.”
While commending the government for its enormous effort at polio eradication, the authors hope their observation “will help at optimizing the dose schedule of OPV administration” to prevent paralysis in vaccinated children.
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